ʻEkolu mau kumuʻaʻole e hopohopo no kāu LDL
ʻOiai ka nui o nā hōʻailona olakino e hoʻonui mau i kaʻai pāʻani liʻiliʻi ( triglycerides , cholesterol HDL, glucose toto, kahe koko, ka wela a hāhā / poʻo, a me nā mea'ē aʻe), he paʻakikī ka hopena o ka lob i ka LDL cholesterol. me ka emiʻana o ka poʻe aʻo kekahi hoʻi he piʻi. Hiki i kekahi poʻe hopohopo keʻike lākou i ka piʻiʻana o kēlā hua'ōlelo,ʻoiaiʻo kā lākou mau kauka e hoʻokō nei i ka'ōlelo kākau.
Akā, aia iʻekolu mau kumu e hā ai i ka hohonu hohonu ma mua o ka hana houʻana aku.
He aha ke Cholesterol?
ʻO Cholesterol he waiwai ia e pili ana i nā momona. ʻOiai ua kapaʻiaʻo LDL cholesterol i ka "ʻino," ke manaʻo nei au he mea nui e hoʻomaopopo i ka cholesterol, ma ka mea pono'ī,ʻaʻoleʻo ia he hewa - he mea pono e holo kā mākou kino. ʻAʻole hiki ke hōʻole i ka hihia e'ōlelo e make mākou me kaʻole cholesterol. ʻO Cholesterol kekahi hapa o ko mākou mau pūmele a me ka hahaki myelin e hoʻonāuki nei i kā mākou mau pūnaewele. Hoʻohanaʻia nō hoʻi i ka hanaʻana i ka nui o kā mākou mau hormones (e like me ka estrogen a me ka testosterone), ka huaʻa D, nā mea nui i ka lepoʻana, aʻoi aku. Hoʻoponoponoʻia kā mākou kino i ka cholesterol - ma muli o kā mākou mau meaʻai, i 80-100% o ka cholesterol i loko o ko mākou kino i "hale".
He aha ka LDL Cholesterol a he aha ka meaʻino no ia mea?
He mea maʻamau ke kamaʻilio e pili ana i nāʻano "cholesterol", akāʻaʻole pono kēia.
ʻO nā kinokona likeʻole me ka likeʻole; ʻo ia wale nō i hōʻailonaʻia i nāʻano likeʻole e laweʻia ai ma o mākou koko. ʻO ka "hoʻokele waʻa" i kapaʻia he lipoprotein. He pōkoleʻo HDL no "lipoprotein kiʻekiʻe loa" a i kekahi manawa ua kapaʻiaʻo "cholesterol maikaʻi". L-LLL no ka "lipoprotein haʻahaʻa" a ua kapaʻiaʻo "cholesterol maikaʻi".
(Hoʻokahi ke kolu, i kapaʻiaʻo VLDL no "lipoprotein haʻahaʻa-haʻahaʻa", hiki ke kapaʻia he "cholesterol maʻamau", akā heʻuʻuku loa ia.)ʻO LDL ka mea pili loa i ka maʻi maʻi e pili ana i nā pāpale ma ke kele.
Akā e kali, ua nui aku! Hoʻokaʻawale likeʻiaʻo HDL a me LDL i nāʻano likeʻole, aʻikeʻia nā mea hou e pili ana i nā "mahele o nāʻano" o lipoproteins. I keʻano o LDL,ʻo ka nui loa o kaʻokoʻa i loko o keʻano,ʻo ia ka nui a me ka māmā o nā mea'āpana o LDL. Ua hōʻike nā kānaka he nuiʻole ka helu LDL a pau loa i kaʻikeʻana i ka mea e hele ai e loaʻa i ka maʻi maʻi, akā,ʻo kaʻikeʻana o nā mamana o ka nui o nā mea nui ua hāʻawi i nā kauka i kaʻike hou e pili ana i ka hopena o ka LDL o kekahi ke kanaka. Akā,ʻoi aʻe e pili ana i kēlā mea i # 2 ma lalo - mua, makemake au e haʻi pokole:
1. LDL Kūkulu Kūpono Loa
Ua nui nā haʻawina e nānā nei i ka nānā aku i ka LDL ma kahi meaʻai iki. Ma kekahi o lākou, aia ka manaʻo o kekahi poʻe e hoʻokiʻekiʻe i ka LDL ma ka māhele 3-4, akā ma ka mahina 6 aiʻole 8 paha, e hoʻomau ana e hoʻi i lalo. Ua lohe au i nā moʻolelo he nui me kēia mau laina mai ka poʻe kaʻa haʻahaʻa. No laila, he mea noʻonoʻo ke pale i kou lima mai ke kī pāʻani i nā mahina mua o kāu polokalamu kīʻaha haʻahaʻa.
(ʻO ke kumu o kēiaʻano, e like me kaʻu iʻike ai,ʻaʻoleʻikeʻia, akā ua'ōleloʻia, e hiki ke hoʻokuʻuʻia ka cholesterol i loko o nā momona momona i loko o ke kahe o ke koko i loko o ka poho kaumaha, a he mea nui loa paha i nā mahina mua i hala ke kau E wikiwiki loa ka poho kaumaha.)
2. NĀ KUMU LAWENI MAʻE MAʻE MAKAHI I KA MAʻUʻU MAʻUʻEʻE
No laila, no ke aha mākou e noʻonoʻo ai i ka nui o nā mea laulā o LDL? Ke huli ia i ka manawa he nui aku nā mea liʻiliʻi o LDL (i kapaʻiaʻo Pattern B),ʻoi aku kaʻike o ke maʻi o ke kala keʻe ke ma mua o ka nui a me ka liʻiliʻi o nā mea nui (Model A).
Ma kēlā me kēia aʻoʻana,ʻike au i ka nānāʻana i ka nui o ka mea nui o ka LDL i ka wā e hele ai nā kānaka i kahi meaʻai haʻahaʻa, ua hoʻololiʻia nā'ōnaehana i ke ala maikaʻi.
No ke aha e palekana ai nā mea keu nui? Ua lohe wau i kekahi mea hoʻopuka hoʻolālā a ka mea kākauʻo Dr. Mark Houston (lohe i ka nīnau maanei - maʻAukake 25, 2012, hōʻike o "E nīnau iā Dr. Dawn"). Ua weheweheʻo ia ma mua o ka noʻonoʻo o ka cholesterol wale nō i ke kūkuluʻana i loko o ke kehau, hoʻomaka ia ma ke kola o ke keʻe ma lalo o ka epithelium (e like me ka "ʻili" o ke kekona) i ka wā e loaʻa ai kaʻino a me ka mumū ma ka epithelium.
ʻO Cholesterol (aiʻole, pololei aku, lipoprotein) mau hua'ōlelo mai ke koko a laila e noho i loko o kēia kāʻei epishelial a kūkuluʻia mai laila mai e hoʻokumu i ka pāpale. I kona uluʻana, hoʻomaka ka pāpale e kāpae i ke keʻe. Ma ka weheweheʻana i ka hopena o ka mea nui, ua hāʻawiʻo Kauka Houston i kēia kahaki: E noʻonoʻo i kaʻupena ma ka papaʻaina. ʻAʻole e komo ka pōleʻele pāʻani i kēlāʻupena, akā ināʻoe e hoʻolei i nā pōlele golf ma kēlāʻupena, e hele kekahi o lākou. Hōʻike kēia i ka manaʻo koʻikoʻi o ka noʻonoʻo no ke kumu nui loa o nā'enela LDL aʻoi aku kaʻino ma mua o ka nui o nā "particulars" -ʻo ka mea liʻiliʻi,ʻoi aku kaʻoi aku o nā meaʻoi aʻe i hiki ke noho ma kahiʻeha o ke ana. (Ke'ōlelo neiʻo Kauka Houston, he mea nui ka helu o nā lālā LDL.)
ʻAʻoleʻoe eʻike e pili ana i nā lālā LDL ma kahi ho'āʻo cholesterol maʻamau. Pono kāu kauka e kauoha i kahi hoʻokolohua kūikawā. ʻO kēia nā mea maʻamau loa:
- Hōʻoia Pūnaewele Vertical (VAP)
- 'Elepili Gel Palena (GGE)
3. LDL hoʻohanaʻoleʻia i ka manawa kūpono, ka mea hiki iā ia ke pilikia
Huliʻia he mea paʻakikī ke ana pololei iā LDL, no laila, hoʻohana mau nā lālā i kahi hoʻopihapiha e helu ai i ka LDL mai nāʻano lipid blood. Kapaʻiaʻo ia ka hōʻailona Friedewald aʻo kēia: LDL = Ka helu Cholesterol - HDL - (Triglycerides / 5). No ka hapanui o nā kānaka, he pololei loa kēia kulekele, akā e hoʻomaopopoʻia kaʻikeʻana o ka'ikemili hoʻokahi keʻano e "hoʻonui" i kāu helu LDL e hoʻonui i kāu mau huaʻopaʻa e like me kaʻaiʻana i ke kōpaʻa. (ʻAʻole maikaʻi maikaʻi !!ʻO kēia wale nō ke kuhikuhi i kahi pilikia kūpono paha.) I kēia manawa, uaʻikeʻia ke kiʻekiʻe loa o nā triglycerides (ʻoi aku ma 400 mg / dL)ʻaʻole i loaʻa i ka hoʻohālikelike nā hopena maikaʻi. Akā ua ulu ka manaʻo kānalua ke hikiʻole keʻano o ke kīpila i ka LOW (ma lalo o 100) hiki ke hoʻonuiʻia ka LDL ma o ka hoʻohanaʻana i kēiaʻano. Ua hoʻonuiʻia kekahi mau aʻoʻana e pili ana i kēia, a me nā loiloi mai nā kauka e hoʻohana nei i ka hanaʻaʻa a me ke kīpona e like me ka mea i mālamaʻia no ka maʻi nui a me ka maʻi diabet. ʻO nā kānaka ma nāʻano kīʻaha liʻiliʻi e hahai nei i kaʻaiʻai me kaʻikeʻole i ka loaʻaʻana o kā lākou mau pahuhopu i lalo o 100 (ʻo ke kaukaʻo Dr. Mary Vernon, hoʻohana i nā ho'ākāka o kekahi o nā hōʻailona e haʻi iā ia inā e hahai ka mea maʻi i kaʻai ). No laila, inā he haʻahaʻa keʻano o nā mea heʻe a he kiʻekiʻe ka LDL, hiki i ka manaʻo maikaʻi ke noi i kahi hōʻailona e hana pololei i ka LDL ma mua o ka hoʻohanaʻana i ka hoʻopiʻi Friedewald.
Ua kūkulu kekahi o nā pūʻulu i aʻoʻia (Ahmadi et al) i kekahiʻano hoʻohālike'ē aʻe, i kapaʻia heʻokoʻa o Iran. ʻOiai he mea nui e hoʻomaopopo i kēiaʻaelikeʻole iʻaeʻoleʻia ma kaʻahahui olakinoʻAmelika, hiki iā ia keʻoluʻolu e hoʻohālike i kāu LDL-i laweʻia e nā hoʻohālike likeʻole.
ʻO ka mea e mahalo ai, loaʻa pūʻia me nā'āpana triglycerides malalo o 100 keʻano pilikino me ka nui o ka heluna lālā LDL. No laila, inā e hahai anaʻoe i kaʻai haʻahaʻa a me ka haʻahaʻa haʻahaʻa,ʻelua mau kumu e hopohopoʻole ai e pili ana i kāu LDL cholesterol, ma ka liʻiliʻi a hiki i kou hoʻonāʻana hou.
Nā kumuhana:
Ahmadi, et al. ʻO ka hopena o keʻano nui o ke koʻikoʻi triglyceride ma ka LDL-cholesterol. Ka Hale Moʻolelo Hawaiʻi. 2008 Mei, 11 (3): 318-21.
Austin, MA. ʻO Triglyceride, liʻiliʻi, lipoprotein haʻahaʻa haʻahaʻa, a me keʻano o ka phenophone lipoprotein atherogenic. Curr Atheroscler Rep. 2000 Mei, 2 (3): 200-7.
Krauss, Ronald, et al. Nā hopena i hoʻokaʻawaleʻia o ka lawe 'ana i ka' amu a me ka paʻake o ke kaumaha ma ka dyslipidemia atherogenic. Ka PelekaneʻAmelika o ka Nānāʻau Nutuamu 2006 May, 83 (5): 1025-31.
Lamarche, et al. ʻO ka'ōpili LDL liʻiliʻi a liʻiliʻi a me ka pilikia o ka maʻi o ke kaha kokamau: epidemiology, patho-physiology a me nāʻano pono. Ka Makike Meka. 1999 Sep; 25 (3): 199-211.
Lemanski, Paul E. "Ma mua o ke kohoʻana Cholesterol Testing: Ka Mana o ka LDL Palapala Aʻe." CDPHP Medical Messenger. Mei 2004. Kelekia no ka Medicinal Preventive and Cardiovascular Health. 14 Sep. 2008
ʻo Sat, a. al. Loss Liko me kahi Low-Carbohydrate, Mediterranean, aiʻole Low-Fat Diet. Ka New Medicine New Zealand Journal of Medicine 2008; 359: 229-241
ʻO ke kolu o ka hōʻike o ke Kōmike Hoʻonāʻauao Hoʻonaʻauao o ka National Cholesterol (NCEP) ma kaʻikeʻana, ka loiloiʻana, a me ke kākoʻo o ke Cholesterol Kokoke Mahu i nāʻAla (PDF), Iulai 2004, Nā National Institute of Heath: The National Heart, Lung, and Blood Institute.
Toft-Peterson, et al. Nā'āpana liʻiliʻi LDL nui liʻiliʻi -ʻo ka mea hōʻikeʻike o ke maʻi o ke kalakinoʻoiai ua loiloiʻia e nāʻano hanaʻino a me nā CT: kahi hoʻonaʻauao kūkā. ʻO ka wai ola ma ka maʻi a me ka maʻi 2011, 10:21.
Wiki, a. al. Nā Kūlana Low Triglyceride Nā mea i hoʻohālikelikeʻia i ka haʻahaʻa haʻahaʻa lipoprotein Cholesterol. ʻO Arch Pathol Lab Med 2001. 25: 404-5